Obesity/Bibliography

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Reviews

• Shively CA, Register TC, Clarkson TB (2009). "Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation". Am J Primatol 71 (9): 742-51. DOI:10.1002/ajp.20706. PMID 19452515. Research Blogging. ^[e]

• Crowley VEE et al. (2002) Obesity therapy: Altering the energy intake-and- expenditure balance sheet. Nature Reviews Drug Discovery 1:276-286
• Hill, JO. Peters, JC. (1998) Environmental contributions to the obesity epidemic. Science 280, 1371–4
• Grill, HJ. & Kaplan, JM. (2002) The neuroanatomical axis for control of energy balance. Front. Neuroendocrinol 23:2–40
• Berthoud, HR. (2002) Multiple neural systems controlling food intake and body weight. Neurosci. Biobehav. Rev 26:393–428
• Schwartz, MW. et al.(2000) Central nervous system control of food intake. Nature 404:661–71

Leptin

• Cowley, MA. et al.(2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480–484
• Farooqi IS et al. (1999). Effects of recombinant leptin therapy in a child with congenital leptin deficiency. New Eng J Med 341:879-84
• Montague CT, et al. Congenital leptin deficiency is associated with severe early- onset obesity in humans. Nature 387:903-8 (1997).
• Rafael J, Herling AW (2000) Leptin effect in ob/ob mice under thermoneutral conditions depends not necessarily on central satiation Am J Physiol 278:R790–5 PMID 10712302 url=http://ajpregu.physiology.org/cgi/content/full/278/3/R790#Top}}"Reduction of body mass in leptin-treated ob/ob mice was faster than in pair-fed ob/ob controls" (Free full text)

Ghrelin

• Kojima M et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-60
• Cowley MA et al. (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:550-3
• Tschöp M, Smiley DL, & Heiman ML Ghrelin induces adiposity in rodents. Nature 407:908-13 (2000)

PPY

• Batterham RL et al. (2002)Gut hormone PYY3-36 physiologically inhibits food intake. Nature 418:650-4

IL6

• Wallenius V et al. (2002) Interleukin-6-deficient mice develop mature-onset obesity. Nature Medicine 8:75-79

Insulin

• Bruning JC et al. (2000) Role of brain insulin receptor in control of body weight and reproduction. Science 289:2122-5
• Obici, S et al.(2002) Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nature Neurosci 5:566–72

MSH

• Fan W et al. (1997) Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165–8
• Lu D et al. (1994) Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371:799–802
• Huszar D et al. (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131–41
• Seeley R et al. (1997) Melanocortin receptors in leptin effects. Nature 390:349