Carboplatin: Difference between revisions
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==Indications== | ==Indications== | ||
===Human=== | ===Human=== | ||
In the U.S., it is only approved for [[ovarian carcinoma]], but common off-label uses include:<ref>{{citation | |||
| url = http://www.medscape.com/druginfo/dosage?drugid=4551&drugname=Carboplatin+IV&monotype=default | |||
| title = Carboplatin | |||
| publisher = American Society of Health System Pharmacists}}</ref> | |||
*[[carcinoma]]s | |||
**[[endometrial carcinoma]] | |||
**[[neuroendocrine prostate carcinoma]] | |||
**[[small cell lung carcinoma]] | |||
**metastatic and locally advanced [[breast carcinoma]] | |||
*[[leukemia]]s | |||
** [[acute myeloid leukemia]] | |||
*Unspecified histology | |||
**Malignant Tumor of Cervix | |||
**Malignant Tumor of Head and Neck | |||
**Malignant Tumor of Urinary Bladder | |||
**Non-Small Cell Lung Cancer | |||
**Refractory Malignant Tumor of Testis | |||
*Lymphoma | |||
**Progressive Diffuse Large B-Cell Lymphoma | |||
*[[Sarcoma]] | |||
**Refractory [[Ewing's sarcoma]] | |||
**Refractory [[osteosarcoma]] | |||
*Seminoma of Testis, | |||
===Veterinary=== | ===Veterinary=== | ||
It is usually the second chemotherapeutic agent used in [[feline squamous cell carcinoma]]. | It is usually the second chemotherapeutic agent used in [[feline squamous cell carcinoma]]. | ||
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==References== | ==References== | ||
{{reflist|2}} | |||
Revision as of 20:36, 26 June 2010
In oncology, carboplatin is a antineoplastic agent that is an "organoplatinum compound that possesses antineoplastic activity."[1]
As compared to cisplatin, carboplatin has equal (lung cancer, ovarian cancer) or less (germ cell tumors, bladder cancer, head and neck cancer) efficacy but less drug toxicity.[2]
History
In the United States, it was approved with a New Drug Application (NDA) by the FDA in 1989.[3] A generic version was approved with a Abbreviated New Drug Application (ANDA) in 2003.[4]
Indications
Human
In the U.S., it is only approved for ovarian carcinoma, but common off-label uses include:[5]
- carcinomas
- endometrial carcinoma
- neuroendocrine prostate carcinoma
- small cell lung carcinoma
- metastatic and locally advanced breast carcinoma
- leukemias
- Unspecified histology
- Malignant Tumor of Cervix
- Malignant Tumor of Head and Neck
- Malignant Tumor of Urinary Bladder
- Non-Small Cell Lung Cancer
- Refractory Malignant Tumor of Testis
- Lymphoma
- Progressive Diffuse Large B-Cell Lymphoma
- Sarcoma
- Refractory Ewing's sarcoma
- Refractory osteosarcoma
- Seminoma of Testis,
Veterinary
It is usually the second chemotherapeutic agent used in feline squamous cell carcinoma.
Dosage
Carboplatin may be dosed by the Calvert formula:[6]
External links
The most up-to-date information about Carboplatin and other drugs can be found at the following sites.
- Carboplatin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Carboplatin - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Carboplatin - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Carboplatin (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Lokich J, Anderson N (1998). "Carboplatin versus cisplatin in solid tumors: an analysis of the literature.". Ann Oncol 9 (1): 13-21. PMID 9541678.
- ↑ Drugs@FDA. U S Food and Drug Administration
- ↑ Drugs@FDA. U S Food and Drug Administration
- ↑ Carboplatin, American Society of Health System Pharmacists
- ↑ Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE et al. (1989). "Carboplatin dosage: prospective evaluation of a simple formula based on renal function.". J Clin Oncol 7 (11): 1748-56. PMID 2681557.