Interleukin: Difference between revisions

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''Interleukins'' are  [[cytokines]] that are made by one leukocyte, acting on other leukocytes).  
'''Interleukins''' are  [[cytokines]] that are made by one leukocyte, acting on other leukocytes).  
{| class="wikitable"
{| class="wikitable"
<center><u>'''Selected cytokines'''</u></center>
|-
|-
! Name(s)
! Name(s)
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| Il-1a, IL-1b
| Il-1a, IL-1b
| [[monocyte]]s, [[macrophage]]s, [[lymphocyte#B-lymphocyte|B-lymphocytes]], DC
| [[monocyte]]s, [[macrophage]]s, [[lymphocyte#B-lymphocyte|B-lymphocytes]], DC
| Th cells, B cells, NK cells, general inflammation-susceptible
| T<sub>H</sub> cells, B cells, NK cells, general inflammation-susceptible
| Th cell co-stimulation, [[lymphocyte#B-lymphocyte|B-lymphocyte]] maturation and proliferation, NK cell activation, general inflammation
| T<sub>H</sub> cell co-stimulation, [[lymphocyte#B-lymphocyte|B-lymphocyte]] maturation and proliferation, NK cell activation, general inflammation
|-
|-
|  IL-2
|  IL-2
|  Th1 cells  
|  Th1 cells  
|  activated [[lymphocyte#T-lymphocyte|T-]] and [[lymphocyte#B-lymphocyte|B-lymphocytes]], NK cells
|  activated [[lymphocyte#T-lymphocyte|T-]] and [[lymphocyte#B-lymphocyte|B-lymphocytes]], [[natural killer cell]]s
|  growth, proliferation, activation
|  growth, proliferation, activation
|-
|-
|  IL-3
|  IL-3
| Th cells, NK cells
| T<sub>H</sub> cells, NK cells
|[[stem cell]]s, [[mast cell]]s
|[[stem cell]]s, [[mast cell]]s
|stem cell growth and differentiation, mast cells growth and [[histamine]] release   
|stem cell growth and differentiation, [[mast cell]]s growth and [[histamine]] release   
|-
|-
| IL-4
| IL-4
| Th2 cells   
| T<sub>H</sub>2 cells   
|  activated B cells, macrophages, T cells
|  activated B cells, macrophages, T cells
| [[Immunoglobulin#Immuniglobulin G|IgG<sub>1</sub>]] and [[Immunoglobulin#Immuniglobulin A|IgE synthesis]] ,macrophage [[Major histocompatibility complex|MHC Class II]], T cell growth, B cell growth
| [[Immunoglobulin#Immuniglobulin G|IgG<sub>1</sub>]] and [[Immunoglobulin#Immuniglobulin A|IgE synthesis]] ,macrophage [[Major histocompatibility complex|MHC Class II]], T cell growth, B cell growth
|-
|-
|  IL-5
|  IL-5
| Th2 cells
| T<sub>H</sub>2 cells
|  activated B cells
|  activated B lymphocytes
| proliferation and differentiation, [[Immunoglobulin#Immuniglobulin A|IgA synthesis]]
| proliferation and differentiation, [[Immunoglobulin#Immuniglobulin A|IgA synthesis]]
|-
|-
|  IL-6
|  IL-6
| monocytes,  macrophages, T-helper subtype 2 lymphocytes (Th2 cells), stromal cells
| monocytes,  macrophages, T<sub>H</sub>2 lymphocytes, stromal cells
|  activated B cells, plasma cells, stem cells,
|  activated B cells, plasma cells, stem cells,
|differentiate B lymphocytes (B cells) into plasma cells, promotes [[immunoglobulin]] synthesis by B lymphocytes, plasma cell antibody secretion, stem cell differentiation, general acute phase response, increases [[hepcidin]] secretion
|differentiate B lymphocytes into plasma cells, promotes [[immunoglobulin]] synthesis by B lymphocytes, [[plasma cell]] antibody secretion, [[stem cell]] differentiation, general [[acute phase response]], increases [[hepcidin]] secretion
|-
|-
|  IL-7
|  IL-7
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| macrophages and endothelial cells
| macrophages and endothelial cells
|  neutrophils
|  neutrophils
|chemotaxic attraction of neutrophils
|chemotaxic attraction of [[neutrophil]]s
|-
|-
|  IL-10
|  IL-10
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| T<sub>H</sub>2 cells
| T<sub>H</sub>2 cells
|  
|  
| Similar to IL-4
| Similar to IL-4[[Category:Suggestion Bot Tag]]
}}</ref>

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Interleukins are cytokines that are made by one leukocyte, acting on other leukocytes).

Name(s) Source Target Function
Il-1a, IL-1b monocytes, macrophages, B-lymphocytes, DC TH cells, B cells, NK cells, general inflammation-susceptible TH cell co-stimulation, B-lymphocyte maturation and proliferation, NK cell activation, general inflammation
IL-2 Th1 cells activated T- and B-lymphocytes, natural killer cells growth, proliferation, activation
IL-3 TH cells, NK cells stem cells, mast cells stem cell growth and differentiation, mast cells growth and histamine release
IL-4 TH2 cells activated B cells, macrophages, T cells IgG1 and IgE synthesis ,macrophage MHC Class II, T cell growth, B cell growth
IL-5 TH2 cells activated B lymphocytes proliferation and differentiation, IgA synthesis
IL-6 monocytes, macrophages, TH2 lymphocytes, stromal cells activated B cells, plasma cells, stem cells, differentiate B lymphocytes into plasma cells, promotes immunoglobulin synthesis by B lymphocytes, plasma cell antibody secretion, stem cell differentiation, general acute phase response, increases hepcidin secretion
IL-7 marrow and thymus stroma stem cells differentiation
IL-8 macrophages and endothelial cells neutrophils chemotaxic attraction of neutrophils
IL-10 Th2 cells macrophages, B-cells downregulate cytokine production by macrophages, activate B-lymphocytes
IL-12 macrophages, B cells activated Tc cells, natural killer cells In combination with IL-2, differentiate Tc cells into CTL; activate NK
IL-13 TH2 cells Similar to IL-4
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