Methotrexate: Difference between revisions
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{{Image|Methotrexate structure.jpg|right|350px|Structure of Methotrexate.}} | |||
{{Image|Folic acid structure.jpg|right|350px|Folic acid.}} | |||
'''Methotrexate (MTX)''' is a drug used in the treatment of rheumatoid arthritis. It is | '''Methotrexate (MTX)''' is a drug used in the treatment of a variety of [[cancer]]s, and [[autoimmunity|autoimmune]] disorders such as [[asthma]], [[psoriasis]] and [[rheumatoid arthritis]]. It is a nucleic acid anti-metabolite (like 6-MP), and a folic acid antagonist due to its similarity in structure. Specifically, it inhibits [[tetrahydrofolate dehydrogenase]], which prevents the formation of [[tetrahydrofolate]], necessary for synthesis of [[thymidylate]], an essential component of [[DNA]]. | ||
While considered a moderately toxic drug, it is widely used in combination therapy to reduce the does, and side effects, of any one drug. For example, small doses of methotrexate, smaller than those used for cancer, can considerably reduce the amount of systemic [[corticosteroid]]s needed in severe asthma patients. | |||
== common synonyms == | == common synonyms == | ||
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== External links == | == External links == | ||
{{CZMed}} | {{CZMed}}[[Category:Suggestion Bot Tag]] | ||
Latest revision as of 11:01, 18 September 2024
Methotrexate (MTX) is a drug used in the treatment of a variety of cancers, and autoimmune disorders such as asthma, psoriasis and rheumatoid arthritis. It is a nucleic acid anti-metabolite (like 6-MP), and a folic acid antagonist due to its similarity in structure. Specifically, it inhibits tetrahydrofolate dehydrogenase, which prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
While considered a moderately toxic drug, it is widely used in combination therapy to reduce the does, and side effects, of any one drug. For example, small doses of methotrexate, smaller than those used for cancer, can considerably reduce the amount of systemic corticosteroids needed in severe asthma patients.
common synonyms
- Mexate
- Methylaminopterin
- Emtexate
- Metatrexan
- Methopterin
- MTX dihydrate
- Folex
- Folex PFS
- Amethopetrin
External links
The most up-to-date information about Methotrexate and other drugs can be found at the following sites.
- Methotrexate - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Methotrexate - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Methotrexate - Detailed information from DrugBank.