Mitosis: Difference between revisions
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'''Mitosis''' is the process during which an [[eukaryotic]] cell divides its [[nucleus]]. | '''Mitosis''' is the process during which an [[eukaryotic]] cell divides its [[nucleus]]. Mitosis is the shortest phase of the [[cell cycle]]. | ||
==Subphases== | ==Subphases== | ||
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===Prophase=== | ===Prophase=== | ||
The condensation of the replicated chromosomes is the first sign that a cell enters into the prophase and into mitosis. Those are first visible as thin threads within the [[nucleus]]. | The condensation of the replicated chromosomes is the first sign that a cell enters into the prophase and into mitosis. Those are first visible as thin threads within the [[nucleus]]. | ||
The [[miotic spindle apparatus]] forms outside of the [[nucleus]] between the two [[centrosome|centrosomes ]]that | The [[miotic spindle apparatus]] forms outside of the [[nucleus]] between the two [[centrosome|centrosomes ]]that separate themselves and begin to move towards opposite poles of the cell. | ||
===Prometaphase=== | ===Prometaphase=== | ||
The prometaphase begins with the break down of the [[nuclear membrane]]. | The prometaphase begins with the break down of the [[nuclear membrane]]. | ||
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==Pathology correlation== | ==Pathology correlation== | ||
In evaluating histologic sections, [[pathologist]]s count the number of cells in field undergoing mitosis. An abnormally high number of cells undergoing mitosis may indicate a [[neoplasm]]. | In evaluating histologic sections, [[pathologist]]s count the number of cells in field undergoing mitosis. An abnormally high number of cells undergoing mitosis may indicate a [[neoplasm]].[[Category:Suggestion Bot Tag]] | ||
Latest revision as of 11:00, 20 September 2024
Mitosis is the process during which an eukaryotic cell divides its nucleus. Mitosis is the shortest phase of the cell cycle.
Subphases
The events during the mitosis happen continuously and are conventionally divided into four or five subphases (not every source treats the prometaphase as distinct phase).
Prophase
The condensation of the replicated chromosomes is the first sign that a cell enters into the prophase and into mitosis. Those are first visible as thin threads within the nucleus. The miotic spindle apparatus forms outside of the nucleus between the two centrosomes that separate themselves and begin to move towards opposite poles of the cell.
Prometaphase
The prometaphase begins with the break down of the nuclear membrane. The chromosomes attach through the kinetochore to the spindle.
Metaphase
The chromosomes arrange themselves in the equatorial plane of the spindle.
Anaphase
The chromatids separate and move to opposite poles of the spindle.
Telophase
New nuclear membranes form around each of chromosome sets and build two daughter nuclei.
Pathology correlation
In evaluating histologic sections, pathologists count the number of cells in field undergoing mitosis. An abnormally high number of cells undergoing mitosis may indicate a neoplasm.