Psoriatic arthritis: Difference between revisions
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'''Psoriatic arthritis''' is a "type of inflammatory [[arthritis]] associated with [[psoriasis]], often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of [[HLA]]-B27-associated [[spondylarthropathy]], and the absence of [[rheumatoid factor]].<ref>{{MeSH}}</ref> | {{subpages}} | ||
'''Psoriatic arthritis''' is a "type of inflammatory [[arthritis]] associated with [[psoriasis]], often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of [[HLA]]-B27-associated [[spondylarthropathy]], and the absence of [[rheumatoid factor]]" (RF).<ref>{{MeSH}}</ref> | |||
==Presentation== | |||
==Definitive diagnosis== | |||
The original diagnostic criteria, not involving genetic analysis, are of Moll & Wright:<ref>{{citation | |||
| author= Moll JMH, Wright V. | |||
| title=Psoriatic arthritis | |||
| journal = Semin Arthritis Rheum | |||
| year = 1973 | |||
| issue=3 | |||
| pages = 55–78}}</ref> Rheumatologists find these still somewhat vague, and also can be confounded by comorbidities. For example, a patient might have [[rheumatoid arthritis]] and have a positive [[rheumatoid factor]] test, but coincidentally have non-arthritic psoriasis. <ref>{{citation | |||
| url = http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1766878&blobtype=pdf | |||
| title = Classification and diagnostic criteria for psoriatic arthritis | |||
| author = P S Helliwell, W J Taylor | |||
| journal = Ann Rheum Dis | |||
| year = 2005 | |||
| issue = 64(Suppl II) | |||
| pages = ii3–ii8. | |||
| doi= 10.1136/ard.2004.032318 | |||
}}</ref> There also may be hidden psoriatic lesions, and Helliwell & Taylor suggest that confirmed psoriasis in a first-degree relative may meet the criteria. | |||
==Treatment== | |||
[[Monoclonal antibody|monoclonal antibodies]] targeting [[tumor necrosis factor]] are the most recent therapy. | |||
==References== | ==References== | ||
{{reflist}} | {{reflist}}[[Category:Suggestion Bot Tag]] | ||
Latest revision as of 06:01, 8 October 2024
Psoriatic arthritis is a "type of inflammatory arthritis associated with psoriasis, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated spondylarthropathy, and the absence of rheumatoid factor" (RF).[1]
Presentation
Definitive diagnosis
The original diagnostic criteria, not involving genetic analysis, are of Moll & Wright:[2] Rheumatologists find these still somewhat vague, and also can be confounded by comorbidities. For example, a patient might have rheumatoid arthritis and have a positive rheumatoid factor test, but coincidentally have non-arthritic psoriasis. [3] There also may be hidden psoriatic lesions, and Helliwell & Taylor suggest that confirmed psoriasis in a first-degree relative may meet the criteria.
Treatment
monoclonal antibodies targeting tumor necrosis factor are the most recent therapy.
References
- ↑ Anonymous (2024), Psoriatic arthritis (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Moll JMH, Wright V. (1973), "Psoriatic arthritis", Semin Arthritis Rheum (no. 3): 55–78
- ↑ P S Helliwell, W J Taylor (2005), "Classification and diagnostic criteria for psoriatic arthritis", Ann Rheum Dis (no. 64(Suppl II)): ii3–ii8., DOI:10.1136/ard.2004.032318