Cytochrome P-450 CYP2D6: Difference between revisions

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{{Image|Mmdbimage-36878.png|right|350px|Crystal Structure of Human Cytochrome P450 2d6.}}
{{Image|Mmdbimage-36878.png|right|350px|Crystal Structure of Human Cytochrome P450 2d6.}}
In [[biology]], the '''cytochrome P-450 CYP2D6''' is a "[[cytochrome P-450]] enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as debrisoquine; [[Adrenergic beta-antagonist|adrenergic receptor antagonist]]s; and [[tricyclic antidepressant]]s. This enzyme is deficient in up to 10 percent of the Caucasian population."<ref>{{MeSH}}</ref><ref>{{OMIM|608902}}</ref>
In [[biology]], the '''cytochrome P-450 CYP2D6''' is a "[[cytochrome P-450]] enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as debrisoquine; [[Adrenergic beta-antagonist|adrenergic receptor antagonist]]s; and [[tricyclic antidepressant]]s. This enzyme is deficient in up to 10 percent of the Caucasian population."<ref>{{MeSH}}</ref><ref>{{OMIM|608902}}</ref>
CYP2D6 may be responsible for metabolism of 25% of prescribed drugs<ref name="pmid10723863">{{cite journal| author=Wolf CR, Smith G| title=Pharmacogenetics. | journal=Br Med Bull | year= 1999 | volume= 55 | issue= 2 | pages= 366-86 | pmid=10723863
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=10723863 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> and 38% of drugs frequently cited for causing [[drug toxicity]]<ref name="pmid11710893">{{cite journal| author=Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W| title=Potential role of pharmacogenomics in reducing drug-related side effects and adverse reactionss: a systematic review. | journal=JAMA | year= 2001 | volume= 286 | issue= 18 | pages= 2270-9 | pmid=11710893
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=11710893 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>.
[[Paroxetine]] may increase death from [[breast cancer]] among women taking [[tamoxifen]] due to inhibiting metabolism of [[tamoxifen]] to its active metabolite by cytochrome P-450 CYP2D6.<ref>{{Cite journal | doi = 10.1136/bmj.c693 | volume = 340 | issue = feb08_1 | pages = c693 | last = Kelly | first = Catherine M | coauthors = David N Juurlink, Tara Gomes, Minh Duong-Hua, Kathleen I Pritchard, Peter C Austin, Lawrence F Paszat | title = Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study
| journal = BMJ | accessdate = 2010-02-10 | date = 2010-02-08 | url = http://www.bmj.com/cgi/content/abstract/340/feb08_1/c693 }}</ref>


==External links==
==External links==
* [[Online Mendelian Inheritance in Man|OMIM]]: [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=124030 124030]
* [[Online Mendelian Inheritance in Man|OMIM]]:
** [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=124030 124030]
** [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608902 CYP2D6-related poor drug metabolism]
* [[Entrez Gene]]: [http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&rn=1&list_uids=1565 1565]; [[PubMed]]: [http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=1565 search]
* [[Entrez Gene]]: [http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&rn=1&list_uids=1565 1565]; [[PubMed]]: [http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=1565 search]
* [http://www.ncbi.nlm.nih.gov/sites/entrez?db=nuccore Entrez Nucleotide]: [http://www.ncbi.nlm.nih.gov/nuccore/68509919 68509919]; [[PubMed]] [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=nuccore_pubmed_weighted&uid=68509919 search]
* [http://www.ncbi.nlm.nih.gov/sites/entrez?db=nuccore Entrez Nucleotide]: [http://www.ncbi.nlm.nih.gov/nuccore/NG_008376 NG_008376]; [[PubMed]] [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=nuccore_pubmed_weighted&uid=68509919 search]
* [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Protein Entrez Protein]: [http://www.ncbi.nlm.nih.gov/protein/40805836 40805836]; [[PubMed]] [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=protein_pubmed_weighted&uid=40805836 search]
* [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Protein Entrez Protein]: [http://www.ncbi.nlm.nih.gov/protein/40805836 40805836]; [[PubMed]] [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=protein_pubmed_weighted&uid=40805836 search]
* [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Structure Entrez Structure]: [http://www.ncbi.nlm.nih.gov/sites/entrez?SUBMIT=y&db=structure&orig_db=structure&term=2F9Q 2F9Q]
* [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Structure Entrez Structure]: [http://www.ncbi.nlm.nih.gov/sites/entrez?SUBMIT=y&db=structure&orig_db=structure&term=2F9Q 2F9Q]

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Crystal Structure of Human Cytochrome P450 2d6.

In biology, the cytochrome P-450 CYP2D6 is a "cytochrome P-450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as debrisoquine; adrenergic receptor antagonists; and tricyclic antidepressants. This enzyme is deficient in up to 10 percent of the Caucasian population."[1][2]

CYP2D6 may be responsible for metabolism of 25% of prescribed drugs[3] and 38% of drugs frequently cited for causing drug toxicity[4].

Paroxetine may increase death from breast cancer among women taking tamoxifen due to inhibiting metabolism of tamoxifen to its active metabolite by cytochrome P-450 CYP2D6.[5]

External links

References

  1. ↑ Anonymous (2024), Cytochrome P-450 CYP2D6 (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 608902. World Wide Web URL: http://omim.org/.
  3. ↑ Wolf CR, Smith G (1999). "Pharmacogenetics.". Br Med Bull 55 (2): 366-86. PMID 10723863.
  4. ↑ Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W (2001). "Potential role of pharmacogenomics in reducing drug-related side effects and adverse reactionss: a systematic review.". JAMA 286 (18): 2270-9. PMID 11710893.
  5. ↑ Kelly, Catherine M; David N Juurlink, Tara Gomes, Minh Duong-Hua, Kathleen I Pritchard, Peter C Austin, Lawrence F Paszat (2010-02-08). "Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study". BMJ 340 (feb08_1): c693. DOI:10.1136/bmj.c693. Retrieved on 2010-02-10. Research Blogging.
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