Talk:Drug treatments for obesity

Mark Cairns 14:38, 6 October 2009 (UTC) Rachael Kirkbride 14:46, 6 October 2009 (UTC) Bruce Traven McLintock 14:47, 6 October 2009 (UTC) Neil R. J. Watson 14:48, 6 October 2009 (UTC)

This page was written by a group of 4 Final Year Physiology Undergraduates at The University of Edinburgh as part of an elective we worked on (September - December 2009) called 'Appetite and Obesity'. It is the culmination of 8-10 weeks of work and is based on our studies both inside and outside the course.

This is a fantastic start - very well done guys. An important issue to focus on is the link between mechanisms of action and physiology - for example on endocannabinoids- where are the CB1 receptors expressed, and how do we think their actions impact on feeding? Gareth Leng 09:26, 13 October 2009 (UTC)

Found a paper in TIPS that you may find interesting, Its called "BAT: a new target for human obesity?" Shane McSweeney 16:35, 13 October 2009 (UTC)

Im impressed, nice work! Celine Caquineau 09:23, 14 October 2009 (UTC)

it seems like everything is going well, good team work! Celine Caquineau 14:38, 21 October 2009 (UTC)

Your article so far: Overall a very good work! You have well understood the task, you show good organisation skills and very good team work with everybody contributing. Well done!

The direction and focus of your article are clear with the help of a good introduction and a well structured plan. You’ve kept in mind that this is an encyclopaedia article, the ‘scientific’ content is well balanced, not too simple not to complex and your writing style makes the article easy to follow by every readers.

I also appreciate that you are keeping an eye on the other articles (Diabetes and Food reward) so you can make links between yours and your peers articles.

Few points:

Im guessing that all the sections are not part of the introduction, modify the title fonts so they appear as separate sections.

You need to insert more references to the facts cited, especially in the first sections. Overall you need to be consistent in typing your references. They should appear in the text as number and in full in ‘References’ at the end of the article and use the Citizendium format. I’ve done an example in 'Peripheral drugs', have a look how I’ve done it. The ‘Bibliography’ page should also be updated accordingly with a consistent format.

I think you can now move your pre-introduction comment (describing the task and who you are) to the top of the Talkpage after all your names.

Finally, don’t hesitate to move references to websites to the ‘External links’ page.

Again, nice work guys, looking forward to read your ‘final’ article. Celine Caquineau 16:29, 28 October 2009 (UTC)

This is really good. The article is well laid out with a clear introduction and concise conlusion and the sub-headings help make the article very readable. Perhaps make the diagram in the "caffeine and ephedrine" section slightly bigger because it's slightly small at the moment but on the whole really good stuff! Amelia Sheldon 14:49, 2 November 2009 (UTC)

I like this page, its really easy to follow and has a good level of detail Andrew Critchley 16:40, 2 November 2009 (UTC)

best page yet! Good job. Shane McSweeney 21:34, 2 November 2009 (UTC)

Great Page! Very easy to follow and understand - plus a great use of images to help out! Amira Mahmoud

I really liked this page, was easy to read and was really nice to see some diagrams/figures. also the level of science seems right for an encyclopedia Robert Parsons 10:20, 3 November 2009 (UTC)

A really good comprehensive article. Nicely laid out. Like the fact you have plenty of diagrams etc. Easy to understand. Good job! Lowri Phillips 12:05, 3 November 2009 (UTC)

this article has a great structure and your diagrams really illustrate your text... i think you've done a really good job! you also seem to have stuck to the word count very well.. very impresive! Rachael White 13:34, 3 November 2009 (UTC)

You;ve done a great job on this article...it's really well laid out and easy to follow..and the picutres are good!

Good balance of text and diagrams. Very informative without being too complicated, overall a very interesting read. Really good page! Rachael Hutt 18:48, 12 November 2009 (UTC)

This article was really easy to read and was very interesting! Great page! Graeme Daniel Logue 19:56, 12 November 2009 (UTC)

Fab page! only thing would be to maybe put a teeny explanation of what 'acyclovir' is? - mentioned with orlistat Hannah Frost 16:57, 13 November 2009 (UTC)

Good use of sub-headings, helps break up the text, and make it really easy to follow. Really good article Sarah Smith 21:18, 14 November 2009 (UTC)

A well written and throughly interesting article. The page layout made it easy to read and the use of diagrams helped to clarify mode of drug action. Well done.

This article is really easy to read, perfect length, the subtitles and layout as well as the figures make things flow really well. Your article helped clarify and put together facts about obesity treatment and drug targets. Katie Gallagher 16:00, 23 November 2009 (UTC)

Feedback

This is an excellent article, very clearly written, concise, interesting and informative. CART is only one of very many neuropeptides that are involved in appetite regulation, and a case could be made for any of these as potential targets for new drugs (and indeed cases are being made all the time for these). It's important to recognise the difficulties with developing new drugs however. First it is important that there be few side effects - so it is important to be sure that, for example, a neuropeptide drug target is involved in appetite but not in too many other things. Drugs need to be given orally, not by injection into the brain, so its important to be able to develop a compound that is not broken down in the gut but which gets into the blood and from there to its target, in the brain or wherever. Its important to know that the drug will be selective for its target - that it acts for example on CART receptors but not other receptors. It's important to know its biological clearance, and that its breakdown products do not have unwanted effects. It's inportant to know that tolerance, desensitisation do not occur in a way that limits its usefulness. etc. So yes it's good to indicate that there are plenty of possible targets that might lead to new drugs - but important to know just how hard it is and how long it takes to develop a useful drug.Gareth Leng 13:52, 19 November 2009 (UTC)

This such as nice and clear article, well done! Celine Caquineau 15:59, 20 November 2009 (UTC)