Cefaclor: Difference between revisions

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'''Cefaclor''', also spelled as '''cephaclor''', is a semisynthetic broad-spectrum  [[antibiotic]] drug used to treat a variety of bacterial infections.  It is a second generation [[cephalosporin]] antibiotic with similar activities.  It is similar in structure to [[cephalexin]] and is also similar to penicillin-like drugs because it contains a [[beta-lactam]] moiety which binds to and interferes with bacterial cell wall synthesis.  It can be used to treat a wide variety of both [[Gram-positive]] and [[Gram-negative]] aerobic bacteria.
'''Cefaclor''', also spelled as '''cephaclor''', is a semisynthetic broad-spectrum  [[antibiotic]] drug used to treat a variety of bacterial infections.  It is a second generation [[cephalosporin]] antibiotic with similar activities.  It is similar in structure to [[cephalexin]] and is also similar to penicillin-like drugs because it contains a [[beta-lactam]] moiety which binds to and interferes with bacterial cell wall synthesis.  It can be used to treat a wide variety of both [[Gram-positive]] and [[Gram-negative]] aerobic bacteria.
== Mechanism of action ==
Because cefaclor is a beta-lactam-based antibiotic, it binds to specific [[penicillin-binding protein]]s located inside the bacterial cell wall and inhibits the final stage of bacterial cell wall synthesis. As a consequence of the defective cell walls, the bacteria cells are autolysed by [[autolysin]]s, autolytic enzymes. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
== Susceptible microbes ==
Among the Gram-postive bacteria, cefaclor has shown activity against [[Staphylococci]], including coagulase-(±) and penicillinase (+) strains, [[Streptococcus pneumoniae]], and [[Streptococcus pyogenes]]. Among the Gram-negative aerobes, cefaclor is active against [[Escherichia coli]], [[Haemophilus influenzae]], including ß-lactamase-producing ampicillin-resistant strains), [[Klebsiella sp]], and [[Proteus mirabilis]].
== Chemistry ==
The IUPAC chemical name for cefaclor is (6R,7R)-7-[(2-amino-2-phenylacetyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, and it has chemical formula C<sub>15</sub>H<sub>14</sub>ClN<sub>3</sub>O<sub>4</sub>S giving it a molecular mass of 367.8074 g/mol.
== Synonyms and brand names ==
{{col-begin}}
{{col-break|width=25%}}
''Synonyms''
* CCL
* Cefaclor anhydrous
* Cefaclorum (Latin)
* Cephaclor 
{{col-break|width=25%}}
''Brand names''
* Alenfral
* Alfacet
* Alfatil
* Ceclor
* Ceclor CD
* Distaclor
* Kefral
* Panacef
* Panoral
* Raniclor
{{col-end}}
== External links ==
{{CZMed}}

Revision as of 15:28, 5 April 2009

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(CC) Image: David E. Volk
cefaclor (cephaclor)
IUPAC name: see chemistry section
Synonyms: cephaclor
Formula: C15H14ClN3O4S
 Uses: antibiotic drug
 Properties: beta-lactam
 Hazards: see drug interactions
Mass (g/mol): CAS #:
367.8074 53994-73-3



Cefaclor, also spelled as cephaclor, is a semisynthetic broad-spectrum antibiotic drug used to treat a variety of bacterial infections. It is a second generation cephalosporin antibiotic with similar activities. It is similar in structure to cephalexin and is also similar to penicillin-like drugs because it contains a beta-lactam moiety which binds to and interferes with bacterial cell wall synthesis. It can be used to treat a wide variety of both Gram-positive and Gram-negative aerobic bacteria.

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