Nitrofurantoin: Difference between revisions
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imported>Robert Badgett (New page: {{subpages}} In medicine, '''nitrofurantion''' is an antibiotic that is a "urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfo...) |
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In [[medicine]], '''nitrofurantion''' is an antibiotic that is a "urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression."<ref>{{MeSH}}</ref> | In [[medicine]], '''nitrofurantion''' is an [[antibiotic]] that is a "urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression."<ref>{{MeSH}}</ref> | ||
Nitrofurantoin achieves good renal and urinary concentrations, but not serum good concentrations.<ref name="url">{{cite web |url=http://www.hopkins-abxguide.org/ |title=Nitrofurantion |author=Pham P, Bartlett JG |authorlink= |coauthors= |date=2008 |format= |work= |publisher=Johns Hopkins Antibiotic Guide |pages= |language= |archiveurl= |archivedate= |quote= |accessdate=2008-10-05}}</ref> | |||
==Effectiveness== | |||
[[Randomized controlled trial]]s have shown nirofurantion to be equivalent to trimethoprim-sulfamethoxazole<ref name="pmid10225575">{{cite journal |author=Iravani A, Klimberg I, Briefer C, Munera C, Kowalsky SF, Echols RM |title=A trial comparing low-dose, short-course ciprofloxacin and standard 7 day therapy with co-trimoxazole or nitrofurantoin in the treatment of uncomplicated urinary tract infection |journal=The Journal of antimicrobial chemotherapy |volume=43 Suppl A |issue= |pages=67–75 |year=1999 |month=March |pmid=10225575 |doi= |url=http://jac.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=10225575 |issn=}}</ref> and ciprofloxacin<ref name="pmid10225575"/><ref name="pmid17998493">{{cite journal |author=Gupta K, Hooton TM, Roberts PL, Stamm WE |title=Short-course nitrofurantoin for the treatment of acute uncomplicated cystitis in women |journal=Archives of internal medicine |volume=167 |issue=20 |pages=2207–12 |year=2007 |month=November |pmid=17998493 |doi=10.1001/archinte.167.20.2207 |url=http://archinte.ama-assn.org/cgi/pmidlookup?view=long&pmid=17998493 |issn=}}</ref> in treating uncomplicated [[urinary tract infection]]s (cystitis). | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 20:00, 5 October 2008
In medicine, nitrofurantion is an antibiotic that is a "urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression."[1]
Nitrofurantoin achieves good renal and urinary concentrations, but not serum good concentrations.[2]
Effectiveness
Randomized controlled trials have shown nirofurantion to be equivalent to trimethoprim-sulfamethoxazole[3] and ciprofloxacin[3][4] in treating uncomplicated urinary tract infections (cystitis).
References
- ↑ Anonymous (2024), Nitrofurantoin (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Pham P, Bartlett JG (2008). Nitrofurantion. Johns Hopkins Antibiotic Guide. Retrieved on 2008-10-05.
- ↑ 3.0 3.1 Iravani A, Klimberg I, Briefer C, Munera C, Kowalsky SF, Echols RM (March 1999). "A trial comparing low-dose, short-course ciprofloxacin and standard 7 day therapy with co-trimoxazole or nitrofurantoin in the treatment of uncomplicated urinary tract infection". The Journal of antimicrobial chemotherapy 43 Suppl A: 67–75. PMID 10225575. [e]
- ↑ Gupta K, Hooton TM, Roberts PL, Stamm WE (November 2007). "Short-course nitrofurantoin for the treatment of acute uncomplicated cystitis in women". Archives of internal medicine 167 (20): 2207–12. DOI:10.1001/archinte.167.20.2207. PMID 17998493. Research Blogging.