Tigecycline: Difference between revisions

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(New page: '''Tigecycline''' is the first commercially available antibiotic of the glycylcycline class, which are a new family based on tetracyclines, but with molecular modifications to evad...)
 
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'''Tigecycline''' is the first commercially available antibiotic of the [[glycylcycline]] class, which are a new family based on [[tetracycline]]s, but with molecular modifications to evade some, but not all, tetracycline resistance mechanisms. <ref>{{citation
'''Tigecycline''' is the first commercially available antibiotic of the [[glycylcycline]] class, which are a new family based on [[tetracycline]]s, but with molecular modifications to evade some, but not all, tetracycline resistance mechanisms. <ref>{{citation
  | title = Tigecycline: what is it, and where should it be used?
  | title = Tigecycline: what is it, and where should it be used?

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Tigecycline is the first commercially available antibiotic of the glycylcycline class, which are a new family based on tetracyclines, but with molecular modifications to evade some, but not all, tetracycline resistance mechanisms. [1] Tetracycline resistance... [2]

Its labeled indications are:[3]

  • Complicated Appendicitis
  • Complicated Bacterial Peritonitis
  • Complicated Skin and Skin Structure Infection
  • Complicated Skin and Skin Structure E. Coli Infection
  • Complicated Skin and Skin Structure Enterococcus faecalis Infection,

  • Infectious Disease of Abdomen
  • Intra-Abdominal Abscess*
  • Legionella pneumophila Pneumonia
  • Streptococcal Pneumonia

Mechanism of action

The drug evades the Tet(A-E) efflux pumps[4] which account for most acquired resistance to tetracycline and minocycline in Enterobacteriaceae and Acinetobacter spp.; also the Tet(K) pumps, which occur widely in staphylococci conferring resistance to tetracycline though not minocycline or doxycycline.[2] It binds to bacterial ribosomes that have been modified by the Tet(M) protein,Cite error: Closing </ref> missing for <ref> tag


References

  1. ↑ David M. Livermore (2005), "Tigecycline: what is it, and where should it be used?", Journal of Antimicrobial Chemotherapy 56 (4): 611-614, DOI:10.1093/jac/dki291
  2. ↑ 2.0 2.1 Chopra I (1986), "Genetic and biochemical basis of tetracycline resistance", J Antimicrob Chemother 18 (Suppl C): 51–6
  3. ↑ Tigecycline IV, American Society of Health-System Pharmacists
  4. ↑ Petersen PJ, Jacobus NV, Weiss WJ et al. In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936). Antimicrob Agents Chemother 1999; 43: 738–44
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