Systemic lupus erythematosus
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Diagnosis
Alternative criteria
Recursive partitioning has been used to identify more parsimonious criteria. [1] This analysis presented two diagnostic classification trees:
1. Simplest classification tree: LSE is diagnosed if the patient has an immunologic disorder (anti-DNA antibody, anti-Smith antibody, false positive syphilis test, or LE cells) or malar rash.
- sensitivity = 92%
- specificity = 92%
2. Full classification tree: Uses 6 criteria.
- sensitivity = 97%
- specificity = 95%
Other alternative criteria have been suggested.[2]
References
- ↑ 1.0 1.1 Edworthy SM, Zatarain E, McShane DJ, Bloch DA (1988). "Analysis of the 1982 ARA lupus criteria data set by recursive partitioning methodology: new insights into the relative merit of individual criteria". J. Rheumatol. 15 (10): 1493-8. PMID 3060613. [e]
- ↑ Hughes GR (1998). "Is it lupus? The St. Thomas' Hospital "alternative" criteria". Clin. Exp. Rheumatol. 16 (3): 250-2. PMID 9631744. [e]