Darusentan

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darusentan

IUPAC name:	(2S)-2-(4,6-dimethoxypyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid
Synonyms:
Formula:	C₂₂H₂₂N₂O₆

Uses:

hypertension

Properties:

Hazards:

see side effects & drug interactions

Mass (g/mol):	CAS #:
410.41988	171714-84-4

In medicine, darusentan is a medication for treating hypertension that is a selective endothelin type A antagonist. It is a vasodilator.^[1]

Drug toxicity

Fluid retention is the most common drug toxicity.^[1]

↑ ^1.0 ^1.1 Weber MA et al. (2009) A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial. Lancet DOI:10.1016/S0140-6736(09)61500-2