Allostasis and allostatic load/External Links

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• John D. and Catherine T. MacArthur Research Network on Socioeconomic Status and Health: Allostatic Load and Allostasis
• Summary prepared by Bruce McEwen and Teresa Seeman in collaboration with the Allostatic Load Working Group. Last revised 1999.
• Chapter Contents:

• Introduction
• Where Stress Fits In
• Allostasis and Allostatic Load
• Allostatic Load Requires Understanding of Physiological Mechanisms
• Validation of Allostatic Load
• Further Refinement of Allostatic Load
• References

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• John D. and Catherine T. MacArthur Research Network on Socioeconomic Status and Health: Allostatic Load and Allostasis Notebook
• Table of Contents

• Allostatic Load and Allostasis
• Antibody Response to an Antigenic Challenge
• Body Composition
• Cardiovascular Measures of Allostatic Load
• Catecholamines and Environmental Stress
• Central Body Fat
• Decrease in Cell-mediated Immunity - A Marker for Allostatic Load Effects on Immune Function
• Dietary Factors and SES
• Fibrinogen is a Candidate Measure of Allostatic Load
• Heart Rate Variability
• Memory Function and Hippocampal Formation Volume
• Modes of Cardiac Control
• Muscle Tension
• Parasympathetic Function
• Salivary Cortisol Measurement and Challenge Tests
• Sleep Quantity and Endocrine Markers of Sleep Quality
• Vital Exhaustion - A Syndrome of Psychological Distress

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• Allostasis to Maintain Homeostasis: U.C. Berkeley - MCB135k: Physiology of the Aging Process

• Wear and tear are caused not only by changes in function but also by repeated fluctuations of various physiological systems and/or long-term exposure to elevated levels of physiological activity.
• Homeostasis: emphasis is on steady state and optimal set points.
• Allostasis: emphsis is on optimal operating ranges of physiological systems.
• Effects of cumulative effects of stress on health and longevity.
• Allostatic Load: stability through change represents the cumulative, multi-system view of physiological toll that may be exacted on the body through attempts at adaptation.
• An organism must vary all parameters of its internal milieu and match them appropriately to environmental demands.

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• Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology