Cervical cancer
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Screening
In a randomized controlled trial, the addition of Human papillomavirus testing to screenng for cervical cancer "reduces the incidence of grade 2 or 3 cervical intraepithelial neoplasia or cancer detected by subsequent screening examinations."[1]
Papanicolaou smear
A systematic review of available studies found the follow results.[2]
| ASCUS or worse | High grade or worse | |||
|---|---|---|---|---|
| sensitivity | specificity | sensitivity | specificity | |
| Conventional method | 88% | 71% | 55% | 97% |
| Liquid-based thin prep | 88% | 71% | 57% | 97% |
A more recent study of the convention method reported very similar results:[1]
- sensitivity 55%
- specificity 94%
Human papillomavirus testing
- sensitivity 95%[1]
- specificity 97%[1]
Combined testing
If either the Papanicolaou smear or Human papillomavirus testing are abnormal:
- sensitivity 100%[1]
- specificity 93%[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Human Papillomavirus and Papanicolaou Tests to Screen for Cervical Cancer. Retrieved on 2007-10-18. Cite error: Invalid
<ref>tag; name "pmid17942871" defined multiple times with different content - ↑ 2.0 2.1 Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch P, Siebers AG, Bulten J (2008). "Liquid Compared With Conventional Cervical Cytology: A Systematic Review and Meta-analysis". Obstet Gynecol 111 (1): 167–177. DOI:10.1097/01.AOG.0000296488.85807.b3. PMID 18165406. Research Blogging.