File:CO2-O2-fMRI-all-over-time.png
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Summary
| Title / Description
|
Functional magnetic resonance imaging of the human brain during gas challenges. Instead of normal air, the participants inhaled either pure oxygen (hyperoxia condition), or 95% oxygen and 5% carbon dioxide (hypercapnic hyperoxia). Yellow (hyperoxia) and green (hypercapnic hyperoxia) overlays of regions of significant signal response in 14 children at five successive time periods during the challenges (time scale below images). For location guide, see Image:Brain-MRI-location-guide.png. As shown by images in the top rows, multiple brain regions responded to hyperoxia, but addition of 5% CO2 to the gas mixture altered the timing or greatly reduced most responses (bottom rows), and eliminated all responses after 48 s. Statistical threshold p = 0.05, false discovery rate correction. |
|---|---|
| Author(s)
|
Macey et al., 2007 |
| Copyright holder
|
Macey et al., 2007 See below for license/re-use information. |
| Source
|
Fig. 2 from Macey PM, Woo MA, Harper RM (2007). "Hyperoxic brain effects are normalized by addition of CO2". PLoS Med 4 (5): e173. DOI:10.1371/journal.pmed.0040173. PMID 17518514. PMC PMC1872042. Research Blogging. [e] |
| Date created
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June 26, 2006 |
| Country of first publication
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United States |
| Notes
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| Other versions
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Image:CO2-O2-fMRI-hyperoxia-over-time.png and Image:CO2-O2-fMRI-hypercapnic-hyperoxia-over-time.png |
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