Desloratadine

Desloratadine
IUPAC name: 8-chloro-6,11-dihydro-11-(4-piperdinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine Synonyms: Clarinex Formula: C19H19Cl4N2
Uses:	rhinitis, urticaria, puritis, hives
Properties:	tricyclic histamine antagonist
Hazards:
Mass (g/mol): CAS #: 310.8

Desloratadine (Clarinex) is a light blue tablet used as an anahistamine and are available by prescription only in the United States. Each tablet contains 5 milligrams desloratadine which are taken orally (by mouth). The powder is white to off-white and is slightly soluble in water. It is very soluble in ethanol andpropylene glycol. The molecular weight for Clarinex (Desloratadine) is 310.8. It is a long acting tricyclic histamine antagonist with selective H₁-receptor histamine antagonist activity.

Usage

Patients 12 and older can take 5 milligrams of Clarinex once daily to help alleviate allergic rhinitis symptoms including both nasal and non-nasal symptoms. Clarinex can also be used to treat hives (uticaria).

Pregnancy and lactation

Clarinex is classified as a class C drug by the Federal Drug Administration. The drug does pass through breast milk.

Reported adverse affects

Clarinex had a 2 percent or greater incidence of the following adverse side affects which include: pharyngitis, dry mouth, myalgia, fatigue, somnolence, dysmenorrhea in that order.

Overdose

Follow standard treatments to remove the unabsorbed drug and provide supportive care. Clarinex is not removed through hemodyalisis.

References

The most up-to-date information about Desloratadine and other drugs can be found at the following sites.

• Desloratadine - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Desloratadine - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
• Desloratadine - Detailed information from DrugBank.