Paraneoplastic cerebellar degeneration
Jump to navigation
Jump to search
In neurology and oncology, paraneoplastic cerebellar degeneration is a type of nervous system paraneoplastic syndrome and is a "cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and gait ataxia; dysarthria; and nystagmus, pathologic. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals."[1][2]
Treatment
Intravenous immunoglobulins
References
- ↑ Anonymous (2023), Paraneoplastic cerebellar degeneration (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Dalmau J, Gonzalez RG, Lerwill MF (2007). "Case records of the Massachusetts General Hospital. Case 4-2007. A 56-year-old woman with rapidly progressive vertigo and ataxia.". N Engl J Med 356 (6): 612-20. DOI:10.1056/NEJMcpc069035. PMID 17287482. Research Blogging.